Three year outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder.

Published version

Published version
Repository DOI

Loading...
Thumbnail Image
Type
Article
Change log
Authors
Pasco, Greg 
Hendry, Alexandra 
Bazelmans, Tessel 
Abstract

BACKGROUND: Most research on early outcomes in infants with a family history (FH) of autism has focussed on categorically defined autism, although some have language and developmental delays. Less is known about outcomes in infants with a FH of attention deficit hyperactivity disorder (ADHD). METHODS: Infants with and without a FH of autism and/or ADHD, due to a first-degree relative with either or both conditions, were recruited at 5 or 10 months. Three year outcomes were characterised using latent profile analysis (LPA) across measures of cognitive ability, adaptive functioning and autism, ADHD and anxiety traits (n = 131). We additionally ran an LPA using only autism and ADHD measures, and the broader LPA in an independent cohort (n = 139) and in both cohorts combined (n = 270). RESULTS: A Low Developmental Level + High Behavioural Concerns class had elevated autism, ADHD and anxiety scores, low cognitive and adaptive function, and included all but one child with autism. A Low Developmental Level + Typical Behaviour class had average cognitive ability and typical behaviour but low adaptive function. A Typical Developmental Level + Some Behavioural Concerns class had average cognitive and adaptive function but slightly elevated behaviour scores. A High Developmental Level + Typical Behaviour class had above average cognitive ability and typical behaviour. All four LPAs identified classes characterised by combinations of either, or both, Low Development Level and elevated behaviour scores, as well as a typically developing class. No classes had elevated autism or ADHD traits in isolation. CONCLUSIONS: Some infants with a FH of autism or ADHD have atypical developmental and behavioural outcomes, but do not show strong autism or ADHD traits in isolation. The field needs to recalibrate aims and methods to embrace the broader transdiagnostic pattern of outcomes seen in these infants.

Description

Funder: Autistica; doi: http://dx.doi.org/10.13039/501100008161


Funder: South London and Maudsley NHS Foundation Trust; doi: http://dx.doi.org/10.13039/100009362


Funder: King's College London; doi: http://dx.doi.org/10.13039/501100000764


Funder: University of London; doi: http://dx.doi.org/10.13039/501100000779

Keywords
ADHD, autism, early childhood, infancy, latent profile analysis
Journal Title
JCPP Adv
Conference Name
Journal ISSN
2692-9384
2692-9384
Volume Title
Publisher
Wiley
Sponsorship
MRC (MR/T003057/1)
Medical Research Council (MR/K021389/1)
Medical Research Council (G0701484)