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Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase

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cam.issuedOnline2018-06-15
dc.contributor.authorAleeva, Y
dc.contributor.authorMaira, G
dc.contributor.authorScopelliti, M
dc.contributor.authorVinciguerra, V
dc.contributor.authorScandurra, G
dc.contributor.authorCannata, G
dc.contributor.authorGiusi, G
dc.contributor.authorCiofi, C
dc.contributor.authorFiga, V
dc.contributor.authorOcchipinti, LG
dc.contributor.authorPignataro, BG
dc.contributor.orcidOcchipinti, Luigi [0000-0002-9067-2534]
dc.date.accessioned2018-12-22T00:31:01Z
dc.date.available2018-12-22T00:31:01Z
dc.date.issued2018
dc.description.abstractFocusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 \mu \text{A}/({\mathrm {mM}} \cdot {\mathrm {cm}}^{2}) are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).
dc.description.sponsorshipLuigi
dc.identifier.doi10.17863/CAM.34691
dc.identifier.eissn1558-1748
dc.identifier.issn1530-437X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/287387
dc.language.isoeng
dc.publisherInstitute of Electrical and Electronics Engineers (IEEE)
dc.publisher.urlhttp://dx.doi.org/10.1109/jsen.2018.2831779
dc.subjectAmperometric sensors
dc.subjectbiosensors
dc.subjectchemical and biological sensors
dc.subjectconductive films
dc.subjectpolymer films
dc.subjectremote sensing
dc.subjectthick film biosensors
dc.titleAmperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase
dc.typeArticle
dcterms.dateAccepted2018-04-16
prism.endingPage4878
prism.issueIdentifier12
prism.publicationDate2018
prism.publicationNameIEEE Sensors Journal
prism.startingPage4869
prism.volume18
rioxxterms.licenseref.startdate2018-06-15
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review
rioxxterms.versionAM
rioxxterms.versionofrecord10.1109/JSEN.2018.2831779

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