Mitochondrial Transcription and Translation: Overview


Type
Article
Change log
Authors
D'Souza, aaron 
Abstract

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the inner membrane of the organelle are involved in the oxidative phosphorylation required for ATP production. Thirteen subunits of these complexes are encoded by the mitochondrial genome often referred to as mtDNA. For this reason, the expression of mtDNA is vital for the assembly and functioning of the oxidative phosphorylation complexes. Defects of the mechanisms regulating mtDNA gene expression have been associated with deficiencies in assembly of these complexes, resulting in mitochondrial diseases. Recently, numerous factors involved in these processes have been identified and characterised leading to a deeper understanding of the mechanisms that underlie mitochondrial diseases.

Description
Keywords
mitochondria, translation, trascription, Adenosine Triphosphate, DNA, Mitochondrial, Humans, Mitochondria, Mitochondrial Diseases, Oxidative Phosphorylation, Protein Biosynthesis, RNA, Messenger, RNA, Transfer, RNA, Transfer, Amino Acyl, Ribosomes, Transcription, Genetic
Journal Title
Essays in Biochemistry
Conference Name
Journal ISSN
0071-1365
1744-1358
Volume Title
62
Publisher
Portland Press, Ltd.
Sponsorship
Medical Research Council (MC_U105697135)
Medical Research Council (MC_UU_00015/4)