Repository logo
 

A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus

Simple item page
cam.issuedOnline2022-05-11
dc.contributor.authorMerchant, monique
dc.contributor.authorPerez Mata, carlos
dc.contributor.authorLiu, yangci
dc.contributor.authorZhai, haomin
dc.contributor.authorProtasio, anna
dc.contributor.authorModis, Yorgo
dc.contributor.orcidMerchant, Monique [0000-0002-6783-7193]
dc.contributor.orcidMata, Carlos P [0000-0003-3381-7431]
dc.contributor.orcidLiu, Yangci [0000-0001-8843-3529]
dc.contributor.orcidProtasio, Anna V [0000-0003-1723-800X]
dc.contributor.orcidModis, Yorgo [0000-0002-6084-0429]
dc.date.accessioned2022-06-12T01:06:31Z
dc.date.available2022-06-12T01:06:31Z
dc.date.issued2022-05-13
dc.date.updated2022-06-12T01:06:31Z
dc.description.abstractEndogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus – an intact retrovirus-like EVE in the human hookworm Ancylostoma ceylanicum, with an envelope protein genetically related to GN-GC glycoproteins from the Phenuiviridae family. A cryo-EM structure of Atlas GC reveals a class II viral membrane fusion protein fold not previously seen in retroviruses. Atlas GC has the structural hallmarks of an active fusogen. Atlas GC trimers insert into membranes with endosomal lipid compositions and low pH. When expressed on the plasma membrane, Atlas GC has cell-cell fusion activity. With its preserved biological activities, Atlas GC has the potential to acquire a cellular function. Our work reveals structural plasticity in reverse-transcribing RNA viruses.
dc.identifier.doi10.17863/CAM.85429
dc.identifier.eissn2375-2548
dc.identifier.issn2375-2548
dc.identifier.other35544562
dc.identifier.otherPMC9094657
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/338024
dc.languageeng
dc.language.isoeng
dc.publisherAmerican Association for the Advancement of Science
dc.publisher.urlhttp://dx.doi.org/10.1126/sciadv.abj6894
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101653440
dc.sourceessn: 2375-2548
dc.subjectAncylostomatoidea
dc.subjectAnimals
dc.subjectHumans
dc.subjectPhlebovirus
dc.subjectRNA Viruses
dc.subjectViral Envelope Proteins
dc.subjectViral Fusion Proteins
dc.subjectVirus Internalization
dc.titleA bioactive phlebovirus-like envelope protein in a hookworm endogenous virus
dc.typeArticle
dcterms.dateAccepted2022-03-25
prism.issueIdentifier19
prism.publicationNameScience Advances
prism.volume8
pubs.funder-project-idWellcome Trust (101908/Z/13/Z)
pubs.funder-project-idNational Institute of General Medical Sciences (R01GM102869)
pubs.funder-project-idWellcome Trust (217191/Z/19/Z)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1126/sciadv.abj6894

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
article.pdf
Size:
1.34 MB
Format:
Adobe Portable Document Format
Description:
Published version
Licence
https://creativecommons.org/licenses/by/4.0/
Download

Collections

Jisc Publications Router