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Antimicrobial resistance in commensal Escherichia coli from humans and chickens in the Mekong Delta of Vietnam is driven by antimicrobial usage and potential cross-species transmission.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Yen, Nguyen Thi Phuong 
Dung, Nguyen Thi Thuy 
Nhan, Nguyen Thi Minh 
Phu, Doan Hoang 

Abstract

OBJECTIVES: To investigate phenotypic antimicrobial resistance (AMR) in relation to antimicrobial use (AMU) and potential inter-species transmission among Escherichia coli from humans and chickens located in the same households in the Mekong Delta of Vietnam. METHODS: We collected data on AMU and faecal swabs from humans (N = 426) and chickens (N = 237) from 237 small-scale farms. From each sample, one E. coli strain was isolated and tested for its susceptibility against 11 antimicrobials by Sensititre AST. The association between AMR and AMU was investigated by logistic regression modelling. Using randomization, we compared the degree of similarity in AMR patterns between human and chicken E. coli from the same farms compared with isolates from different farms. RESULTS: The AMU rate was ∼19 times higher in chickens (291.1 per 1000 chicken-days) than in humans (15.1 per 1000 person-days). Isolates from chickens also displayed a higher prevalence of multidrug resistance (63.3%) than those of human origin (55.1%). AMU increased the probability of resistance in isolates from human (ORs between 2.1 and 5.3) and chicken (ORs between 1.9 and 4.8). E. coli from humans and chickens living on same farms had a higher degree of similarity in their AMR patterns than isolates from humans and chicken living on different farms. CONCLUSIONS: We demonstrated the co-influence of AMU and potential transmission on observed phenotypic AMR patterns among E. coli isolates from food-producing animals and in-contact humans. Restricting unnecessary AMU alongside limiting interspecies contact (i.e. increasing hygiene and biocontainment) are essential for reducing the burden of AMR.

Description

Keywords

3207 Medical Microbiology, 32 Biomedical and Clinical Sciences, 3211 Oncology and Carcinogenesis, Infectious Diseases, Emerging Infectious Diseases, Antimicrobial Resistance, 2 Aetiology, 2.2 Factors relating to the physical environment, Infection

Journal Title

JAC Antimicrob Resist

Conference Name

Journal ISSN

2632-1823
2632-1823

Volume Title

4

Publisher

Oxford University Press (OUP)
Sponsorship
Wellcome Trust (110085/Z/15/Z)