Thiazole formation through a modified Gewald reaction.


Type
Article
Change log
Authors
Mallia, Carl J 
Englert, Lukas 
Walter, Gary C 
Abstract

The synthesis of thiazoles and thiophenes starting from nitriles, via a modified Gewald reaction has been studied for a number of different substrates. 1,4-Dithiane-2,5-diol was used as the aldehyde precursor to give either 2-substituted thiazoles or 2-substituted aminothiophenes depending on the substitution of the α-carbon to the cyano group.

Description
Keywords
1,4-dithiane-2,5-diol, Gewald reaction, design of experiment (DOE), thiazole, thiophene
Journal Title
Beilstein J Org Chem
Conference Name
Journal ISSN
1860-5397
1860-5397
Volume Title
11
Publisher
Beilstein Institut