Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.
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Authors
Abstract
NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD-NACHT linker and one in the NACHT itself.
Description
Keywords
Caspase activation and recruitment domain, Crohn’s Disease, Innate immunity, Nucleotide-binding leucine-rich repeat containing receptor, Signal transduction, Stress kinase pathway, Adaptor Proteins, Signal Transducing, Animals, CARD Signaling Adaptor Proteins, Humans, Mice, Models, Molecular, Nod2 Signaling Adaptor Protein, Protein Binding, Protein Structure, Tertiary
Journal Title
FEBS Lett
Conference Name
Journal ISSN
0014-5793
1873-3468
1873-3468
Volume Title
Publisher
Wiley
Publisher DOI
Sponsorship
This work was funded by a Wellcome Trust Career Development Fellowship (WT085090MA) to TPM and a Medical Research Council grant (U117565398) to KR. RP and JPB were supported by BBSRC Doctoral Training Grants.