The following data files are provided: Summary of results: numerical values used to plot each figure in the manuscript, as well as values used to calculate each parameter when applicable. Raw macroindentation and microindentation data: the load vs. time curves obtained by spherical indentation on a universal testing machine and on an AFM. Confocal data: contains representative confocal datasets, presented as .lsm files, for each physical cryogel sample in the neutral and activated states. READ ME: A word document describing each file and its contents.