Repository logo

Management of asymptomatic severe aortic stenosis: a systematic review and meta-analysis.

Published version



Change log


Tsampasian, Vasiliki  ORCID logo
Grafton-Clarke, Ciaran 
Gracia Ramos, Abraham Edgar  ORCID logo
Asimakopoulos, George 
Garg, Pankaj 


OBJECTIVES: The management of severe aortic stenosis mandates consideration of aortic valve intervention for symptomatic patients. However, for asymptomatic patients with severe aortic stenosis, recent randomised trials supported earlier intervention. We conducted a systematic review and meta-analysis to evaluate all the available data comparing the two management strategies. METHODS: PubMed, Cochrane and Web of Science databases were systematically searched from inception until 10 January 2022. The search key terms were 'asymptomatic', 'severe aortic stenosis' and 'intervention'. RESULTS: Meta-analysis of two published randomised trials, AVATAR and RECOVERY, included 302 patients and showed that early intervention resulted in 55% reduction in all-cause mortality (HR=0.45, 95% CI 0.24 to 0.86; I2 0%) and 79% reduction in risk of hospitalisation for heart failure (HR=0.21, 95% CI 0.05 to 0.96; I2 15%). There was no difference in risk of cardiovascular death between the two groups (HR=0.36, 95% CI 0.03 to 3.78; I2 78%). Additionally, meta-analysis of eight observational studies showed improved mortality in patients treated with early intervention (HR=0.38, 95% CI 0.26 to 0.56; I2 77%). CONCLUSION: This meta-analysis provides evidence that, in patients with severe asymptomatic aortic stenosis, early intervention reduces all-cause mortality and improves outcomes compared with conservative management. While this is very encouraging, further randomised controlled studies are needed to draw firm conclusions and identify the optimal timing of intervention. PROSPERO REGISTRATION NUMBER: CRD42022301037.


Funder: National Institute for Health Research (NIHR)


aortic diseases, aortic valve stenosis, meta-analysis, Aortic Valve, Aortic Valve Stenosis, Conservative Treatment, Heart Failure, Humans, Transcatheter Aortic Valve Replacement

Journal Title

Open Heart

Conference Name

Journal ISSN


Volume Title



Engineering and Physical Sciences Research Council (EP/N014588/1)
Medical Research Council (1966157)
EPSRC (EP/T017961/1)