Signalling dynamics, cell decisions, and homeostatic control in health and disease.

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Valls, Pablo Oriol 
Esposito, Alessandro  ORCID logo

Cell signalling engenders cells with the capability to receive and process information from the intracellular and extracellular environments, trigger and execute biological responses, and communicate with each other. Ultimately, cell signalling is responsible for maintaining homeostasis at the cellular, tissue and systemic level. For this reason, cell signalling is a topic of intense research efforts aimed to elucidate how cells coordinate transitions between states in developing and adult organisms in physiological and pathological conditions. Here, we review current knowledge of how cell signalling operates at multiple spatial and temporal scales, focusing on how single-cell analytical techniques reveal mechanisms underpinning cell-to-cell variability, signalling plasticity, and collective cellular responses.

Adult, Homeostasis, Humans, Signal Transduction
Journal Title
Curr Opin Cell Biol
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Elsevier BV
MRC (unknown)
Cancer Research UK (C54674/A27487)
Cancer Research UK (A25117)
MRC (MC_UU_12022/8)
Medical Research Council (MC_UU_12022/1)
A.E. acknowledges the financial support provided by the CRUK with a multi-disciplinary project award (OncoLive, C54674/A27487), pump-priming funds from the CRUK Cambridge Center (C9685/A25117, C9685/A28397). A.E. also acknowledges financial support from Medical Research Council program grants (MC_UU_12022/1 and MC_UU_12022/8) awarded to the MRC Cancer Unit. P.O.V. acknowledges the financial support of the MRC Doctoral Training Award (ref. 1753414) granted to the MRC Cancer Unit.