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A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves.

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Chen, Joshua C 
Kan, Peter 
Yu, Zhanghao 


Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals' sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.


Funder: NIH U18EB029353, NSF GRFP

Funder: NIH U18EB029353

Funder: NIH R01DE021798, NSF GRFP

Funder: NIH R01DE021798


Animals, Electric Power Supplies, Proof of Concept Study, Prostheses and Implants, Rats, Sciatic Nerve, Swine, Wireless Technology

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Nat Biomed Eng

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Springer Science and Business Media LLC