Near Infrared Spectroscopy for High-Temporal Resolution Cerebral Physiome Characterization in TBI: A Narrative Review of Techniques, Applications, and Future Directions.


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Authors
Gomez, Alwyn 
Sainbhi, Amanjyot Singh 
Froese, Logan 
Batson, Carleen 
Alizadeh, Arsalan 
Abstract

Multimodal monitoring has been gaining traction in the critical care of patients following traumatic brain injury (TBI). Through providing a deeper understanding of the individual patient's comprehensive physiologic state, or "physiome," following injury, these methods hold the promise of improving personalized care and advancing precision medicine. One of the modalities being explored in TBI care is near-infrared spectroscopy (NIRS), given it's non-invasive nature and ability to interrogate microvascular and tissue oxygen metabolism. In this narrative review, we begin by discussing the principles of NIRS technology, including spatially, frequency, and time-resolved variants. Subsequently, the applications of NIRS in various phases of clinical care following TBI are explored. These applications include the pre-hospital, intraoperative, neurocritical care, and outpatient/rehabilitation setting. The utility of NIRS to predict functional outcomes and evaluate dysfunctional cerebrovascular reactivity is also discussed. Finally, future applications and potential advancements in NIRS-based physiologic monitoring of TBI patients are presented, with a description of the potential integration with other omics biomarkers.

Description
Keywords
Pharmacology, traumatic brain injury, near-infrared spectroscopy, cerebrovascular reactivity, multi-modal monitoring, precision medicine
Journal Title
Front Pharmacol
Conference Name
Journal ISSN
1663-9812
1663-9812
Volume Title
12
Publisher
Frontiers Media SA