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Bacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism.

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cam.issuedOnline2021-12-31
dc.contributor.authorKatsuya-Gaviria, Kai
dc.contributor.authorParis, Giulia
dc.contributor.authorDendooven, Tom
dc.contributor.authorBandyra, Katarzyna J
dc.contributor.orcidKatsuya-Gaviria, Kai [0000-0002-0818-7477]
dc.contributor.orcidParis, Giulia [0000-0002-5610-2722]
dc.contributor.orcidDendooven, Tom [0000-0002-9847-0910]
dc.contributor.orcidBandyra, Katarzyna J [0000-0003-2607-6700]
dc.date.accessioned2022-05-22T01:06:59Z
dc.date.available2022-05-22T01:06:59Z
dc.date.issued2022
dc.date.updated2022-05-22T01:06:58Z
dc.description.abstractIn all domains of life, RNA chaperones safeguard and guide the fate of the cellular RNA pool. RNA chaperones comprise structurally diverse proteins that ensure proper folding, stability, and ribonuclease resistance of RNA, and they support regulatory activities mediated by RNA. RNA chaperones constitute a topologically diverse group of proteins that often present an unstructured region and bind RNA with limited nucleotide sequence preferences. In bacteria, three main proteins - Hfq, ProQ, and CsrA - have been shown to regulate numerous complex processes, including bacterial growth, stress response and virulence. Hfq and ProQ have well-studied activities as global chaperones with pleiotropic impact, while CsrA has a chaperone-like role with more defined riboregulatory function. Here, we describe relevant novel insights into their common features, including RNA binding properties, unstructured domains, and interplay with other proteins important to RNA metabolism.
dc.identifier.doi10.17863/CAM.84792
dc.identifier.eissn1555-8584
dc.identifier.issn1547-6286
dc.identifier.other35438047
dc.identifier.otherPMC9037510
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/337378
dc.languageeng
dc.language.isoeng
dc.publisherInforma UK Limited
dc.publisher.urlhttp://dx.doi.org/10.1080/15476286.2022.2048565
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourcenlmid: 101235328
dc.sourceessn: 1555-8584
dc.subjectC-terminal domain
dc.subjectCsrA
dc.subjectHfq
dc.subjectProQ
dc.subjectRNA chaperone
dc.subjectRNA metabolism
dc.subjectRiboregulation
dc.subjectBacteria
dc.subjectBacterial Proteins
dc.subjectGene Expression Regulation, Bacterial
dc.subjectHost Factor 1 Protein
dc.subjectMolecular Chaperones
dc.subjectRNA, Bacterial
dc.subjectRNA, Small Untranslated
dc.subjectRNA-Binding Proteins
dc.titleBacterial RNA chaperones and chaperone-like riboregulators: behind the scenes of RNA-mediated regulation of cellular metabolism.
dc.typeArticle
prism.endingPage436
prism.issueIdentifier1
prism.publicationNameRNA Biol
prism.startingPage419
prism.volume19
pubs.funder-project-idEuropean Commission (101038064)
pubs.funder-project-idnarodowe centrum nauki (2020/37/K/NZ1/02312, 2020/39/D/NZ1/01651)
pubs.funder-project-idWellcome Trust (200873/Z/16/Z)
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1080/15476286.2022.2048565

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