Continuous Pd-Catalyzed Carbonylative Cyclization Using Iron Pentacarbonyl as a CO Source.


Type
Article
Change log
Authors
Abstract

This work discloses a continuous flow carbonylation reaction using iron pentacarbonyl as source of CO. The described transformation using this surrogate was designed for use in commonly accessible flow equipment. Optimized conditions were applied to a scalable synthesis of the natural compound isolated from perianal glandular pheromone secretion of the African civet cat. In addition, a flow Pd-catalyzed carbonylation of aryl halides is successfully reported.

Description
Keywords
3405 Organic Chemistry, 34 Chemical Sciences
Journal Title
J Org Chem
Conference Name
Journal ISSN
0022-3263
1520-6904
Volume Title
84
Publisher
American Chemical Society (ACS)
Rights
All rights reserved
Sponsorship
Slovak Grant Agencies (APVV-14-0147 and VEGA o. 1/0552/18)