Biparental inheritance of mitochondrial DNA revisited.
Accepted version
Peer-reviewed
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Abstract
Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA, and highlight the co-amplification of rare, concatenated nuclear mtDNA segments as a technical artefact that may explain previous observations.
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Keywords
DNA, Mitochondrial, Humans, Maternal Inheritance, Paternal Inheritance
Journal Title
Nat Rev Genet
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Journal ISSN
1471-0056
1471-0064
1471-0064
Volume Title
22
Publisher
Springer Science and Business Media LLC
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All rights reserved
Sponsorship
Wellcome Trust (212219/Z/18/Z)
Medical Research Council (MC_UU_00015/7)
Medical Research Council (MC_UU_00015/7)