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Mapping SARS-CoV-2 antigenic relationships and serological responses

Accepted version
Peer-reviewed

Type

Article

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Authors

Tureli, Sina 
Legresley, Eric 

Abstract

Vaccination has greatly reduced the disease burden of SARS-CoV-2. However, since late 2020, variants have emerged that are able to escape immunity from vaccination and previous infections, including B.1.351 (Beta), P.1 (Gamma), B.1.617.2 (Delta), and B.1.1.529 (Omicron and its descendants). In combination with vaccination, infections with different variants form the basis of current population immunity against SARS-CoV-2.

Description

Keywords

Humans, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Cross Reactions, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Antigens, Viral, mRNA Vaccines, Vaccination, Amino Acid Substitution

Journal Title

Science

Conference Name

Journal ISSN

0036-8075
1095-9203

Volume Title

Publisher

American Association for the Advancement of Science (AAAS)
Sponsorship
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (Option 18B)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-C504-4612)
National Institutes of Health (NIH) (via Mount Sinai School of Medicine (MSSM)) (0258-B504-4612)
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