T lymphocyte senescence is attenuated in Parkinson's disease.
Published version
Peer-reviewed
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Authors
Jensen, Melanie
Papastavrou, Vanesa
Scott, Kirsten M
Kolenda, Claire
Abstract
Background
Immune involvement is well-described in Parkinson's disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson's disease in older age, age-related dysregulation of T lymphocytes may be relevant in this disorder, and we have previously observed changes in age-associated CD8+ T cell subsets in mid-stage PD. This study aimed to further characterise T cell immunosenescence in newly diagnosed PD patients, including shifts in CD4+ and CD8+ subpopulations, and changes in markers of cellular ageing in CD8+ T lymphocytes.Methods
Peripheral blood mononuclear cells were extracted from the blood of 61 newly diagnosed PD patients and 63 age- and sex-matched controls. Flow cytometric analysis was used for immunophenotyping of CD8+ and CD4+ lymphocyte subsets, and analysis of recent thymic emigrant cells. Telomere length within CD8+ T lymphocytes was assessed, as well as the expression of the telomerase reverse transcriptase enzyme (hTERT), and the cell-ageing markers p16INK4a and p21CIP1/Waf1.Results
The number of CD8+ TEMRA T cells was found to be significantly reduced in PD patients compared to controls. The expression of p16INK4a in CD8+ lymphocytes was also lower in patients versus controls. Chronic latent CMV infection was associated with increased senescent CD8+ lymphocytes in healthy controls, but this shift was less apparent in PD patients.Conclusions
Taken together, our data demonstrate a reduction in CD8+ T cell replicative senescence which is present at the earliest stages of Parkinson's disease.Description
Keywords
T lymphocytes, Immunosenescence, Parkinson’s Disease, Ageing Markers
Journal Title
Journal of neuroinflammation
Conference Name
Journal ISSN
1742-2094
Volume Title
18
Publisher
Publisher DOI
Sponsorship
medical research council (MR/R007446/1)
michael j. fox foundation for parkinson's research (14912)
Medical Research Council (MR/R007446/1)
michael j. fox foundation for parkinson's research (14912)
Medical Research Council (MR/R007446/1)