T lymphocyte senescence is attenuated in Parkinson's disease.
Scott, Kirsten M
Solim, Imtiaz H
Williams-Gray, Caroline H
Journal of neuroinflammation
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Kouli, A., Jensen, M., Papastavrou, V., Scott, K. M., Kolenda, C., Parker, C., Solim, I. H., et al. (2021). T lymphocyte senescence is attenuated in Parkinson's disease.. Journal of neuroinflammation, 18 (1) https://doi.org/10.1186/s12974-021-02287-9
<h4>Background</h4>Immune involvement is well-described in Parkinson's disease (PD), including an adaptive T lymphocyte response. Given the increasing prevalence of Parkinson's disease in older age, age-related dysregulation of T lymphocytes may be relevant in this disorder, and we have previously observed changes in age-associated CD8<sup>+</sup> T cell subsets in mid-stage PD. This study aimed to further characterise T cell immunosenescence in newly diagnosed PD patients, including shifts in CD4<sup>+</sup> and CD8<sup>+</sup> subpopulations, and changes in markers of cellular ageing in CD8<sup>+</sup> T lymphocytes.<h4>Methods</h4>Peripheral blood mononuclear cells were extracted from the blood of 61 newly diagnosed PD patients and 63 age- and sex-matched controls. Flow cytometric analysis was used for immunophenotyping of CD8<sup>+</sup> and CD4<sup>+</sup> lymphocyte subsets, and analysis of recent thymic emigrant cells. Telomere length within CD8<sup>+</sup> T lymphocytes was assessed, as well as the expression of the telomerase reverse transcriptase enzyme (hTERT), and the cell-ageing markers p16<sup>INK4a</sup> and p21<sup>CIP1/Waf1</sup>.<h4>Results</h4>The number of CD8<sup>+</sup> TEMRA T cells was found to be significantly reduced in PD patients compared to controls. The expression of p16<sup>INK4a</sup> in CD8<sup>+</sup> lymphocytes was also lower in patients versus controls. Chronic latent CMV infection was associated with increased senescent CD8<sup>+</sup> lymphocytes in healthy controls, but this shift was less apparent in PD patients.<h4>Conclusions</h4>Taken together, our data demonstrate a reduction in CD8<sup>+</sup> T cell replicative senescence which is present at the earliest stages of Parkinson's disease.
T lymphocytes, Immunosenescence, Parkinson’s Disease, Ageing Markers
medical research council (MR/R007446/1)
michael j. fox foundation for parkinson's research (14912)
Medical Research Council (MR/R007446/1)
External DOI: https://doi.org/10.1186/s12974-021-02287-9
This record's URL: https://www.repository.cam.ac.uk/handle/1810/330811
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/