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Enhanced Visualization of Optimal Cerebral Perfusion Pressure Over Time to Support Clinical Decision Making.

Accepted version
Peer-reviewed

Repository DOI


Type

Article

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Authors

Aries, Marcel JH 
Wesselink, Robin 
Elting, Jan Willem J 

Abstract

OBJECTIVE: Cerebrovascular reactivity can provide a continuously updated individualized target for management of cerebral perfusion pressure, termed optimal cerebral perfusion pressure. The objective of this project was to find a way of improving the optimal cerebral perfusion pressure methodology by introducing a new visualization method. DATA SOURCES: Four severe traumatic brain injury patients with intracranial pressure monitoring. DATA EXTRACTION: Data were collected and pre-processed using ICM+ software. DATA SYNTHESIS: Sequential optimal cerebral perfusion pressure curves were used to create a color-coded maps of autoregulation - cerebral perfusion pressure relationship evolution over time. CONCLUSIONS: The visualization method addresses some of the main drawbacks of the original methodology and might bring the potential for its clinical application closer.

Description

Keywords

Brain Injuries, Cerebrovascular Circulation, Clinical Decision-Making, Homeostasis, Humans, Intracranial Pressure, Monitoring, Physiologic, Trauma Severity Indices

Journal Title

Crit Care Med

Conference Name

Journal ISSN

0090-3493
1530-0293

Volume Title

Publisher

Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Marcel Aries received an unrestricted grant from the Dutch Society of Intensive Care. Joseph Donnelly is supported by a Woolf Fisher Trust Scholarship. The software for brain monitoring ICM+® (www.neurosurg.cam.ac.uk/imcplus) is licensed by the University of Cambridge (Cambridge Enterprise).