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Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study. (2018-11-27)BACKGROUND: Many recent Stroke trials fail to show a beneficial effect of the intervention late in the development. Currently a large number of new treatment options are being developed. Multi-arm multi-stage (MAMS) designs ...
Sequence homology and expression profile of genes associated with DNA repair pathways in Mycobacterium leprae. (2017-10)BACKGROUND: Survival of Mycobacterium leprae, the causative bacteria for leprosy, in the human host is dependent to an extent on the ways in which its genome integrity is retained. DNA repair mechanisms protect bacterial ...