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  • Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. 

    Bridges, Hannah R; Blaza, James N; Yin, Zhan; Chung, Injae; Pollak, Michael N; Hirst, Judy (American Association for the Advancement of Science (AAAS), 2023-01-27)
    The molecular mode of action of biguanides, including the drug metformin, which is widely used in the treatment of diabetes, is incompletely characterized. Here, we define the inhibitory drug-target interaction(s) of a ...
  • Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study. 

    Zhao, Jian; Stewart, Isobel D; Baird, Denis; Mason, Dan; Wright, John; Zheng, Jie; Gaunt, Tom R et al. (Elsevier BV, 2023-01-23)
    BACKGROUND: Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. METHODS: We explored the ...
  • The association between plasma zinc concentrations and markers of glucose metabolism in adults in Cameroon. 

    Mba, Camille M; Jones, Kerry S; Forouhi, Nita G; Imamura, Fumiaki; Assah, Felix; Mbanya, Jean Claude; Wareham, Nicholas J (Cambridge University Press (CUP), 2023-01-25)
    An abnormal zinc status has been suggested to play a role in the pathogenesis of type 2 diabetes. However, epidemiological studies of the relationship between plasma zinc concentrations and diabetes are sparse and inconclusive. ...
  • Carbon footprint estimation for computational research 

    Lannelongue, loic; Inouye, Michael
    Data analysis relies heavily on computation, and algorithms have grown more demanding in terms of hardware and energy. Monitoring their environmental impacts is and will continue to be an essential part of sustainable ...

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