Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung
Condliffe, Alison M.
Peters, A. Mike
Chilvers, Edwin R.
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Loutsios, C., Farahi, N., Simmonds, R., Cullum, I., Gillett, D., Solanki, C., Solanki, K., et al. (2015). Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung. Thorax, 70 1085-1086. https://doi.org/10.1136/thoraxjnl-2015-207156
This is the final version of the article. It first appeared from the BMJ Group via http://dx.doi.org/10.1136/thoraxjnl-2015-207156
The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to single-photon emission computed tomography (SPECT) has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with antineutrophil cytoplasmic antibody-positive vasculitis. Here, we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.
This work was supported by Asthma-UK (08/11), the Medical Research Council (grant number MR/J00345X/1), the Wellcome Trust (grant number 098351/Z/12/Z), and Cambridge NIHR Biomedical Research Centre.
External DOI: https://doi.org/10.1136/thoraxjnl-2015-207156
This record's URL: https://www.repository.cam.ac.uk/handle/1810/252661
Attribution 2.0 UK: England & Wales
Licence URL: http://creativecommons.org/licenses/by/2.0/uk/
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