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A corrected formulation for marginal inference derived from two-part mixed models for longitudinal semi-continuous data

Published version
Peer-reviewed

Type

Article

Change log

Authors

Tom, BD 
Farewell, VT 

Abstract

For semi-continuous data which are a mixture of true zeros and continuously distributed positive values, the use of two-part mixed models provides a convenient modelling framework. However, deriving population-averaged (marginal) effects from such models is not always straightforward. Su et al. presented a model that provided convenient estimation of marginal effects for the logistic component of the two-part model but the specification of marginal effects for the continuous part of the model presented in that paper was based on an incorrect formulation. We present a corrected formulation and additionally explore the use of the two-part model for inferences on the overall marginal mean, which may be of more practical relevance in our application and more generally.

Description

Keywords

bridge distribution, excess zeros, longitudinal data, random effects

Journal Title

Statistical Methods in Medical Research

Conference Name

Journal ISSN

0962-2802
1477-0334

Volume Title

25

Publisher

SAGE Publications
Sponsorship
This work was supported by the Medical Research Council (Unit Programme number U105261167).