Parsing the Roles of the Frontal Lobes and BG in Task Control Using Multivoxel Pattern Analysis
Journal of Cognitive Neuroscience
Massachusetts Institute of Technology Press
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Kehagia, A., Ye, R., Joyce, D., Doyle, O., Rowe, J., & Robbins, T. (2017). Parsing the Roles of the Frontal Lobes and BG in Task Control Using Multivoxel Pattern Analysis. Journal of Cognitive Neuroscience, 29 (8), 1390-1401. https://doi.org/10.1162/jocn_a_01130
Cognitive control has traditionally been associated with pFC based on observations of deficits in patients with frontal lesions. However, evidence from patients with Parkinson's disease indicates that subcortical regions also contribute to control under certain conditions. We scanned 17 healthy volunteers while they performed a task-switching paradigm that previously dissociated performance deficits arising from frontal lesions in comparison with Parkinson's disease, as a function of the abstraction of the rules that are switched. From a multivoxel pattern analysis by Gaussian Process Classification, we then estimated the forward (generative) model to infer regional patterns of activity that predict Switch/Repeat behavior between rule conditions. At 1000 permutations, Switch/Repeat classification accuracy for concrete rules was significant in the BG, but at chance in the frontal lobe. The inverse pattern was obtained for abstract rules, whereby the conditions were successfully discriminated in the frontal lobe but not in the BG. This double dissociation highlights the difference between cortical and subcortical contributions to cognitive control and demonstrates the utility of multivariate approaches in investigations of functions that rely on distributed and overlapping neural substrates.
This research was sponsored by a Wellcome Trust grant (076274/Z/04/Z) to T. W. R., B. J. Everitt, A. C. Roberts, and B. J. Sahakian and was completed at the University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council and the Wellcome Trust, as well as a Wellcome Trust Senior Investigator Award to T. W. R. (104631/Z/14/Z) and a Senior Fellowship award to J. B. R. (103838). A. A. K. was supported by an Isaac Newton fellowship and the Wellcome Trust (077029). R. Y. is grateful for support from the China Scholarship Council (CSC). D. W. J. is an NIHR academic clinical lecturer. O. M. D. gratefully acknowledges support from the Engineering and Physical Sciences Research Council (EPSRC grant EP/L000296/1).
WELLCOME TRUST (103838/Z/14/Z)
Wellcome Trust (076274/Z/04/Z)
Wellcome Trust (093875/Z/10/Z)
WELLCOME TRUST (104631/Z/14/Z)
Medical Research Council (MC_U105597119)
MEDICAL RESEARCH COUNCIL (G0001354)
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External DOI: https://doi.org/10.1162/jocn_a_01130
This record's URL: https://www.repository.cam.ac.uk/handle/1810/264226