Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants.
Public Library of Science (PLoS)
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Alaa, A. M., Bolton, T., Di Angelantonio, E., Rudd, J., & van der Schaar, M. (2019). Cardiovascular disease risk prediction using automated machine learning: A prospective study of 423,604 UK Biobank participants.. PloS one, 14 (5), e0213653. https://doi.org/10.1371/journal.pone.0213653
Identifying people at risk of cardiovascular diseases (CVD) is a cornerstone of preventative cardiology. Risk prediction models currently recommended by clinical guidelines are typically based on a limited number of predictors with sub-optimal performance across all patient groups. Data-driven techniques based on machine learning (ML) might improve the performance of risk predictions by agnostically discovering novel risk predictors and learning the complex interactions between them. We tested (1) whether ML techniques based on a state-of-the-art automated ML framework (AutoPrognosis) could improve CVD risk prediction compared to traditional approaches, and (2) whether considering non-traditional variables could increase the accuracy of CVD risk predictions.
Humans, Cardiovascular Diseases, Prognosis, Population Surveillance, Proportional Hazards Models, Risk Assessment, Risk Factors, Prospective Studies, Reproducibility of Results, Algorithms, Biological Specimen Banks, Female, Male, Machine Learning, United Kingdom
British Heart Foundation (PG/09/083/27667)
Academy of Medical Sciences (unknown)
British Heart Foundation (FS/12/29/29463)
WELLCOME TRUST (104492/Z/14/Z)
British Heart Foundation (RG/13/13/30194)
British Heart Foundation (RG/18/13/33946)
Embargo Lift Date
External DOI: https://doi.org/10.1371/journal.pone.0213653
This record's URL: https://www.repository.cam.ac.uk/handle/1810/291537
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