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dc.contributor.authorAgostini, Massimiliano
dc.contributor.authorGanini, Carlo
dc.contributor.authorCandi, Eleonora
dc.contributor.authorMelino, Gerry
dc.date.accessioned2021-02-09T16:33:35Z
dc.date.available2021-02-09T16:33:35Z
dc.date.issued2020-03-12
dc.date.submitted2020-01-27
dc.identifier.others41420-020-0247-6
dc.identifier.other247
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/317398
dc.descriptionFunder: RCUK | Medical Research Council (MRC); doi: https://doi.org/10.13039/501100000265
dc.descriptionFunder: Fondazione Luigi Maria Monti IDI-IRCCS (RC)
dc.description.abstractAbstract: Regulatory noncoding RNAs (ncRNAs) are a class of RNAs transcribed by regions of the human genome that do not encode for proteins. The three main members of this class, named microRNA, long noncoding RNA, and circular RNA play a key role in the regulation of gene expression, eventually shaping critical cellular processes. Compelling experimental evidence shows that ncRNAs function either as tumor suppressors or oncogenes by participating in the regulation of one or several cancer hallmarks, including evading cell death, and their expression is frequently deregulated during cancer onset, progression, and dissemination. More recently, preclinical and clinical studies indicate that ncRNAs are potential biomarkers for monitoring cancer progression, relapse, and response to cancer therapy. Here, we will discuss the role of noncoding RNAs in regulating cancer cell death, focusing on those ncRNAs with a potential clinical relevance.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectReview Article
dc.subject/631/337/384/2568
dc.subject/631/337/384/331
dc.subjectreview-article
dc.titleThe role of noncoding RNAs in epithelial cancer
dc.typeArticle
dc.date.updated2021-02-09T16:33:34Z
prism.issueIdentifier1
prism.publicationNameCell Death Discovery
prism.volume6
dc.identifier.doi10.17863/CAM.64511
dcterms.dateAccepted2020-02-17
rioxxterms.versionofrecord10.1038/s41420-020-0247-6
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidGanini, Carlo [0000-0002-5839-3965]
dc.identifier.eissn2058-7716
pubs.funder-project-idAssociazione Italiana per la Ricerca sul Cancro (Italian Association for Cancer Research) (IG#20473, IG#22206)
pubs.funder-project-idMinistero della Salute (Ministry of Health, Italy) (#PGR00961)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)