HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions.
Authors
Antonescu, Cristina R
Chinnaiyan, Arul
Cree, Ian A
Harrison, Christine J
Hastings, Rosalind J
Huret, Jean-Loup
Johansson, Bertil
Le Beau, Michelle
Mertens, Fredrik
Mitelman, Felix
Publication Date
2021-11Journal Title
Leukemia
ISSN
0887-6924
Publisher
Springer Science and Business Media LLC
Volume
35
Issue
11
Pages
3040-3043
Language
en
Type
Other
This Version
VoR
Metadata
Show full item recordCitation
Bruford, E. A., Antonescu, C. R., Carroll, A. J., Chinnaiyan, A., Cree, I. A., Cross, N. C., Dalgleish, R., et al. (2021). HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions.. [Other]. https://doi.org/10.1038/s41375-021-01436-6
Abstract
Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator-a double colon (::)-to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.
Keywords
Consensus Statement, /631/208/68, /631/208/2489/1381/1853, /631/67/68, /631/208/2489/68, /631/208/69, /45, consensus-statement
Sponsorship
Wellcome Trust (Wellcome) (208349/Z/17/Z)
U.S. Department of Health & Human Services | National Institutes of Health (NIH) (U24HG003345)
Identifiers
s41375-021-01436-6, 1436
External DOI: https://doi.org/10.1038/s41375-021-01436-6
This record's DOI: https://doi.org/10.17863/CAM.77434
Rights
Licence:
http://creativecommons.org/licenses/by/4.0/
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