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Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Cupido, Arjen J https://orcid.org/0000-0003-3300-8124
Kraaijenhof, Jordan M https://orcid.org/0000-0001-7566-6403
Burgess, Stephen https://orcid.org/0000-0001-5365-8760
Asselbergs, Folkert W https://orcid.org/0000-0002-1692-8669
Hovingh, G Kees https://orcid.org/0000-0002-8145-1676
Abstract
Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses
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Journal Title
Circ Genom Precis Med
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Journal ISSN
2574-8300
2574-8300
2574-8300
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Publisher
Ovid Technologies (Wolters Kluwer Health)
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Sponsorship
Wellcome Trust (204623/Z/16/Z)