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Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.

Published version
Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/334707

Repository DOI

https://doi.org/10.17863/CAM.82125
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Published version (464.05 KB)

Type

Article

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Authors

Cupido, Arjen J  ORCID logo  https://orcid.org/0000-0003-3300-8124
Kraaijenhof, Jordan M  ORCID logo  https://orcid.org/0000-0001-7566-6403
Burgess, Stephen  ORCID logo  https://orcid.org/0000-0001-5365-8760
Asselbergs, Folkert W  ORCID logo  https://orcid.org/0000-0002-1692-8669
Hovingh, G Kees  ORCID logo  https://orcid.org/0000-0002-8145-1676

Abstract

Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses

Description

Keywords

cardiovascular diseases, causality, inflammation, linear models, neutrophils, Coronary Artery Disease, Genome-Wide Association Study, Humans, Lymphocytes, Mendelian Randomization Analysis, Neutrophils

Journal Title

Circ Genom Precis Med

Conference Name

Journal ISSN

1942-325X
2574-8300

Volume Title

15

Publisher

Wolters Kluwer

Publisher DOI

https://doi.org/10.1161/CIRCGEN.121.003553

Rights and licensing

Attribution 4.0 International
Except where otherwised noted, this item's license is described as Attribution 4.0 International
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)

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