Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.

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Authors
  Cupido, Arjen J
  Kraaijenhof, Jordan M
  Burgess, Stephen
  Asselbergs, Folkert W
  Hovingh, G Kees
  Gill, Dipender
Publication Date
2022-02
Journal Title
Circ Genom Precis Med
ISSN
2574-8300
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
15
Issue
1
Language
eng
Type
Article
This Version
VoR
Metadata
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Citation
Cupido, A. J., Kraaijenhof, J. M., Burgess, S., Asselbergs, F. W., Hovingh, G. K., & Gill, D. (2022). Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.. Circ Genom Precis Med, 15 (1) https://doi.org/10.1161/CIRCGEN.121.003553
Abstract
Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses
Keywords
Neutrophils, Cardiovascular diseases, Inflammation, Causality, Linear Models
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
Identifiers
PMC7612391, 35103484
External DOI: https://doi.org/10.1161/CIRCGEN.121.003553
This record's URL: https://www.repository.cam.ac.uk/handle/1810/334707
Rights
Attribution 4.0 International
Licence URL: https://creativecommons.org/licenses/by/4.0/
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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International