Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Cupido, Arjen J https://orcid.org/0000-0003-3300-8124
Kraaijenhof, Jordan M https://orcid.org/0000-0001-7566-6403
Burgess, Stephen https://orcid.org/0000-0001-5365-8760
Asselbergs, Folkert W https://orcid.org/0000-0002-1692-8669
Hovingh, G Kees https://orcid.org/0000-0002-8145-1676
Abstract
Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses
Description
Keywords
cardiovascular diseases, causality, inflammation, linear models, neutrophils, Coronary Artery Disease, Genome-Wide Association Study, Humans, Lymphocytes, Mendelian Randomization Analysis, Neutrophils
Journal Title
Circ Genom Precis Med
Conference Name
Journal ISSN
2574-8300
2574-8300
2574-8300
Volume Title
15
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)