Activity-induced instabilities of brain organoids.
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Publication Date
2021-12-07ISSN
1292-8941
Language
eng
Type
Article
This Version
VoR
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Thijssen, K., Kusters, G. L. A., & Doostmohammadi, A. (2021). Activity-induced instabilities of brain organoids.. https://doi.org/10.1140/epje/s10189-021-00149-z
Description
Funder: http://dx.doi.org/10.13039/501100007601; Grant(s): 722497
Abstract
We present an analytical and numerical investigation of the activity-induced hydrodynamic instabilities in model brain organoids. While several mechanisms have been introduced to explain the experimental observation of surface instabilities in brain organoids, the role of activity has been largely overlooked. Our results show that the active stress generated by the cells can be a, previously overlooked, contributor to the emergence of surface deformations in brain organoids.
Sponsorship
Novo Nordisk Fonden (NNF18SA0035142)
Villum Fonden (29476)
Horizon 2020 (847523)
Danmarks Frie Forskningsfond (DFF-117155-1001)
Engineering and Physical Sciences Research Council (EP/T031247/1)
Identifiers
34874504, PMC8651611
External DOI: https://doi.org/10.1140/epje/s10189-021-00149-z
This record's URL: https://www.repository.cam.ac.uk/handle/1810/333076
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