Reaction Time and Visual Memory in Connection to Hazardous Drinking Polygenic Scores in Schizophrenia, Schizoaffective Disorder and Bipolar Disorder.


Type
Article
Change log
Authors
Mazumder, Atiqul Haq  ORCID logo  https://orcid.org/0000-0002-2148-4070
Barnett, Jennifer 
Isometsä, Erkki Tapio  ORCID logo  https://orcid.org/0000-0001-5956-2399
Lindberg, Nina 
Torniainen-Holm, Minna  ORCID logo  https://orcid.org/0000-0003-2149-855X
Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

Description
Keywords
PGS, bipolar disorder, cognition, hazardous drinking, reaction time, schizoaffective disorder, schizophrenia, visual memory
Journal Title
Brain Sci
Conference Name
Journal ISSN
2076-3425
2076-3425
Volume Title
11
Publisher
MDPI AG
Sponsorship
The the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) (0400 584622)
The Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (6045290-5500000710 and 6000009-5500000710)
The H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international pro-grams (COFUND) (713606)