Sleep duration and cardiometabolic risk factors among individuals with type 2 diabetes.

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Cooper, Andrew JM 
Brage, Søren 
Prevost, A Toby 
Griffin, Simon J 

OBJECTIVE: To examine the association between sleep duration and cardiometabolic risk factors among individuals with recently diagnosed type 2 diabetes (n = 391). METHODS: Sleep duration was derived using a combination of questionnaire and objective heart rate and movement sensing in the UK ADDITION-Plus study (2002-2007). Adjusted means were estimated for individual cardiometabolic risk factors and clustered cardiometabolic risk (CCMR) by five categories of sleep duration. RESULTS: We observed a J-shaped association between sleep duration and CCMR - individuals sleeping 7 to <8 h had a significantly better CCMR profile than those sleeping ≥9 h. Independent of physical activity and sedentary time, individuals sleeping 7 to <8 h had lower triacylglycerol (0.62 mmol/l (0.29, 1.06)) and higher high-density lipoprotein (HDL)-cholesterol levels (0.23 mmol/l (0.16, 0.30)) compared with those sleeping ≥9 h, and a lower waist circumference (7.87 cm (6.06, 9.68)) and body mass index (BMI) (3.47 kg/m(2) (2.69, 4.25)) than those sleeping <6 h. Although sleeping 7 to <8 h was associated with lower levels of systolic and diastolic blood pressure, HbA1c, total cholesterol, and low-density lipoprotein (LDL)-cholesterol, these associations were not statistically significant. CONCLUSIONS: Sleep duration has a J-shaped association with CCMR in individuals with diabetes, independent of potential confounding. Health promotion interventions might highlight the importance of adequate sleep in this high-risk population.

BMI, Cardiovascular risk, Lipids, Sleep duration, Type 2 diabetes, Waist circumference, Actigraphy, Adult, Aged, Behavior Therapy, Blood Pressure, Body Mass Index, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Sedentary Behavior, Self Report, Sleep, Time Factors, Triglycerides, Waist Circumference
Journal Title
Sleep Med
Conference Name
Journal ISSN
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Elsevier BV
Medical Research Council (MC_UU_12015/3)
Medical Research Council (G0001164)
Medical Research Council (MC_UU_12015/4)
Wellcome Trust (061895/Z/00/Z)
Medical Research Council (MC_U106179474)
NIHR Central Commissioning Facility (NIHRDH-RP-PG-0606-1259)
Medical Research Council (MC_U106179473)
The trial is supported by the Wellcome Trust, the Medical Research Council, Diabetes UK and National Health Service R&D support funding. SJG was a member of the National Institute for Health Research (NIHR) School for Primary Care Research. The General Practice and Primary Care Research Unit was supported by NIHR Research funds. SJG received support from the Department of Health NIHR Programme Grant funding scheme [RP-PG-0606-1259]. ATP is supported by the NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London.