Decoding accelerometry for classification and prediction of critically ill patients with severe brain injury


Change log
Authors
Bhattacharyay, Shubhayu  ORCID logo  https://orcid.org/0000-0001-7428-5588
Rattray, John 
Wang, Matthew 
Dziedzic, Peter H 
Calvillo, Eusebia 
Abstract

Our goal is to explore quantitative motor features in critically ill patients with severe brain injury (SBI). We hypothesized that computational decoding of these features would yield information on underlying neurological states and outcomes. Using wearable microsensors placed on all extremities, we recorded a median 24.1 (IQR: 22.8–25.1) hours of high-frequency accelerometry data per patient from a prospective cohort (jats:italicn</jats:italic> = 69) admitted to the ICU with SBI. Models were trained using time-, frequency-, and wavelet-domain features and levels of responsiveness and outcome as labels. The two primary tasks were detection of levels of responsiveness, assessed by motor sub-score of the Glasgow Coma Scale (GCSm), and prediction of functional outcome at discharge, measured with the Glasgow Outcome Scale–Extended (GOSE). Detection models achieved significant (AUC: 0.70 [95% CI: 0.53–0.85]) and consistent (observation windows: 12 min – 9 hours) discrimination of SBI patients capable of purposeful movement (GCSm > 4). Prediction models accurately discriminated patients of upper moderate disability or better (GOSE > 5) with 2–6 hours of observation (AUC: 0.82 [95% CI: 0.75–0.90]). Results suggest that time series analysis of motor activity yields clinically relevant insights on underlying functional states and short-term outcomes in patients with SBI.

Description
Keywords
Journal Title
Scientific Reports
Conference Name
Journal ISSN
2045-2322
Volume Title
Publisher
Nature Publishing Group
Sponsorship
This work was partially supported by awards from the Johns Hopkins University Office of the Provost and the Hodson Trust, received by S.B. S.B. is currently funded by a Gates Cambridge fellowship
Relationships
Is previous version of: