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Research data in support of:"Responsive core-shell DNA particles trigger lipid-membrane disruption and bacteria entrapment"

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Brady, Ryan 
Mancini, Leonardo 
Contini, Claudia 
Rubio Sanchez, Roger  ORCID logo


DLS data / images of agarose gels with various DNA constructs proving their successful folding and showing triggered corona displacement from core-shell particles. UV melting curves of non-cholesterolized DNA motifs. Confocal micrographs of DNA particles with fluorescent core and corona, vesicles ruptured and permeabilized by triggered DNA particles, E. coli entrapped in a DNA net formed by triggered DNA particles. TEM micrographs of core-shell DNA particles. Fast frame rate bright-field videos and bright-field images of non-triggered / triggered DNA particles, E. coli entrapped in a DNA net. Epifluorescence micrographs of of non-triggered / triggered DNA particles, E. coli entrapped in a DNA net. Fluorescence measurements showing the progressive leakage of calcein from LUVs. Absorbance measurements used to calculate the lipid concentration in GUVs and LUVs. Optical density measurements showing the bacterial growth in the presence of core-shell DNA particles.


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DNA nanotechnology, Core-shell DNA nanoparticles, Synthetic cells, Biomimicry, Lipid membrane rupture, Lipid membrane permeabilization, Bacteria entrapment


EPSRC (2127174)
Royal Society (UF160152)