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Role of tau deposition in early cognitive decline in Down syndrome.

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Hartley, Sigan L 
Handen, Benjamin L 
Tudorascu, Dana 
Lee, Laise 
Cohen, Annie 


INTRODUCTION: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). METHODS: Data from 123 non-demented adults with DS (M  = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [TH] vs. low tau [TL]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ- vs. Aβ+). RESULTS: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ- group. The Aβ+/TH group evidenced significantly worse episodic memory than the Aβ+/TL group. DISCUSSION: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.



Alzheimer's disease, Down syndrome, amyloid, memory, positron emission tomography, tau

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Alzheimers Dement (Amst)

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National Institute on Aging (R01AG031110, U01AG051406, U19 AG070043)
National Institute on Child Health and Human Development (U54 HD090256, P50 HD105353)